4-[[2-[(2-Methylbenzoyl)amino]ethyl]amino]-1-piperidinecarboxylic acid ethyl ester monohydrochloride
VU 0357017 Hydrochloride
CAS: 1135242-13-5
Molecular Formula: C18H28ClN3O3
4-[[2-[(2-Methylbenzoyl)amino]ethyl]amino]-1-piperidinecarboxylic acid ethyl ester monohydrochloride - Names and Identifiers
4-[[2-[(2-Methylbenzoyl)amino]ethyl]amino]-1-piperidinecarboxylic acid ethyl ester monohydrochloride - Physico-chemical Properties
| Molecular Formula | C18H28ClN3O3 |
| Molar Mass | 369.9 |
| Solubility | DMSO: ≥10mg/mL |
| Appearance | powder |
| Color | white to off-white |
| Storage Condition | Inert atmosphere,2-8°C |
| In vitro study | VU0357017 is selective for M 1 (K i =9.91 µM) over M 2 -M 5 mAChRs (K i =21.4, 55.3, 35.0, and 50.0 μM, respectively) in CHO cells. VU0357017 (1 nM-100 μM) induces calcium release and ERK phosphorylation in a concentration-dependent manner in CHO cells. |
4-[[2-[(2-Methylbenzoyl)amino]ethyl]amino]-1-piperidinecarboxylic acid ethyl ester monohydrochloride - Risk and Safety
| Hazard Symbols | N - Dangerous for the environment |
| Risk Codes | 52/53 - Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment. |
| Safety Description | 61 - Avoid release to the environment. Refer to special instructions / safety data sheets. |
| WGK Germany | 2 |
4-[[2-[(2-Methylbenzoyl)amino]ethyl]amino]-1-piperidinecarboxylic acid ethyl ester monohydrochloride - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.704 ml | 13.518 ml | 27.035 ml |
| 5 mM | 0.541 ml | 2.704 ml | 5.407 ml |
| 10 mM | 0.27 ml | 1.352 ml | 2.704 ml |
| 5 mM | 0.054 ml | 0.27 ml | 0.541 ml |
Last Update：2024-01-02 23:10:35
4-[[2-[(2-Methylbenzoyl)amino]ethyl]amino]-1-piperidinecarboxylic acid ethyl ester monohydrochloride - Reference Information
| biological activity | VU0357017 hydrochloride (CID-25010775) is a potent, central nervous system permeability highly selective M1 agonists, M1 is a class of subtypes of muscarinic acetyl linear receptors (mAChRs). VU0357017 hydrochloride acts at the allosteric site to activate the receptor with an EC50 value of 477 nM and a Ki value of 9.91 μm. |
| Target | Value |
| M1 mAChR (Cell-free assay) | 477 nM(EC50) 9.91 μM(Ki) |
| Animal Model: | Male Sprague−Dawley rats (380-420 g) were pretreated with scopolamine |
| Dosage: | 1, 3, 10 mg/kg |
| Administration: | A single i.p. |
| Result: | Produced a significant reversal of the scopolamine-induced deficits at a dose of 10 mg/kg. |
Last Update：2024-04-09 20:48:19
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Product Name: VU 0357017 Hydrochloride Visit Supplier Webpage Request for quotationCAS: 1135242-13-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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4-[[2-[(2-Methylbenzoyl)amino]ethyl]amino]-1-piperidinecarboxylic acid ethyl ester monohydrochloride